Direct mechanisms may involve GLP-1 receptor activation on vascular endothelial cells, whilst indirect effects result from weight loss, improved glycaemic control, and reduced visceral adiposity, all of which independently lower inflammatory burden
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The drug should be discontinued immediately in the presence of significant hepatic dysfunction, suspected or apparent
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This observation provided the rationale for the development of pharmacological GLP1R agonists, which are now widely used in the treatment of T2D (Ling et al., 2019)